Coherence depression in stochastic excitable systems with two-frequency forcing.

We study the response of two generic neuron models, the leaky integrate-and-fire (LIF) model and the leaky integrate-and-fire model with dynamic threshold (LIFDT) (i.e., with memory) to a stimulus consisting of two sinusoidal drives with incommensurate frequency, an amplitude modulation ("envelope") noise and a relatively weak additive noise. Spectral and coherence analysis of responses to such naturalistic stimuli reveals how the LIFDT model exhibits better correlation between modulation and spike train even in the presence of both noises. However, a resonance-induced synchrony, occurring when the beat frequency between the sinusoids is close to the intrinsic neuronal firing rate, decreases the coherence in the dynamic threshold case. Under suprathreshold conditions, the modulation noise simultaneously decreases the linear spectral coherence between the spikes and the whole stimulus, as well as between spikes and the stimulus envelope. Our study shows that the coefficient of variation of the envelope fluctuations is positively correlated with the degree of coherence depression. As the coherence function quantifies the linear information transmission, our findings indicate that under certain conditions, a transmission loss results when an excitable system with adaptive properties encodes a beat with frequency in the vicinity of its mean firing rate.